Novel LCMS-Compatible icIEF Fractionation for Characterization of Innovator and Biosimilar mAbs

MauriceFlex Fractionation of charge variants accompanied by LC-MS and Digital SPR Analysis correlates Structure to the Function of a mAb Srinivasa Rao1, Samantha Ippoliti2, Ying Qing Yu2, Michael Piazza3, Chris Heger1 Bio-Techne1, San Jose, CA; Waters Corporation2, Milford, MA; Nicoya…

Application Note Charge Variant Characterization of Innovator and Biosimilar Drugs with MauriceFlex™ and BioAccord™ LC-MS System Samantha Ippoliti, Srinivasa Rao, Manisha Pratap, Ying Qing Yu, Chris Heger Waters Corporation, Bio-Techne Abstract This application note showcases an in-depth comparative analysis of…

Application Note Comprehensive Biosimilar Comparability Assessment via Intact and Subunit RP-MS and IEX-UV-MS Using the Xevo™ G3 QTof System Samantha Ippoliti, Owen Cornwell, Lisa Reid, Ying Qing Yu, Emma Harry, Mark Towers Waters Corporation Abstract With the increasing prevalence of…

Characterization and Monitoring of mAb Charge Variants via Online IEX-MS Samantha Ippoliti Waters MS User Meeting ASMS 2019 Atlanta, GA June 1, 2019 ©2019 Waters Corporation 1 Agenda 1. mAb CQA Characterization 2. Reverse Phase vs Ion Exchange Chromatography 3.…