Rapid Determination Of The Pharmacokinetics, Metabolism, Elimination And Tissue Distribution Of A PROTACs Drug Using UHPLC-MS/MS, HRMS And DESI Imaging

Application Note A Rapid UPLC™-MS/MS Method for the Quantification of PROTACs-3-Gefitinib and Urinary Metabolites Following Subcutaneous Administration to Male Rats Robert S. Plumb, Nikunj Tanna Waters Corporation Abstract Proteolysis Targeting Chimera (PROTAC) drugs are now well established in pharmaceutical development…

Tandem Quadrupole DESI Imaging To Visualize Spatial Distribution of Gefitinib and Related Metabolites in Rat Liver Anthony J. Midey,1 Robert Plumb,1 Nikunj Tanna,1 and Ian D. Wilson2 1Waters Corp., Milford, MA, USA; 2Imperial College London, London, UK Study Design Samples…

Application Note Rapid Identification of the In Vivo Biotransformations of a Targeted Protein Degrader (PROTACs) Using Xevo G3 QTof and waters_connect Software Platform Robert S. Plumb Waters Corporation, United States Published on June 05, 2025 Contact Sales Abstract PROteolysis TArgeting…

Application Note Rapid, High Sensitivity Quantification of a Proteolysis Targeting Chimera, PROTAC, in Rat Plasma From a Microsampling DMPK Study Using UPLC-MS/MS Robert S. Plumb Waters Corporation Abstract Proteolysis targeting chimeras are bifunctional molecules with two molecular entities connected by…