A Rapid UPLC™-MS/MS Method for the Quantification of PROTACs-3-Gefitinib and Urinary Metabolites Following Subcutaneous Administration to Male Rats

Rapid Determination Of The Pharmacokinetics, Metabolism, Elimination And Tissue Distribution Of A PROTACs Drug Using UHPLC-MS/MS, HRMS And DESI Imaging. Abstract ID number: 322535 Authors: 1Andrew Leightner, 1Steven K Lai, 1Anthony Midey, 1Robert S Plumb, 2Ian D Wilson Affiliations: 1Waters…

Application Note Rapid Identification of the In Vivo Biotransformations of a Targeted Protein Degrader (PROTACs) Using Xevo G3 QTof and waters_connect Software Platform Robert S. Plumb Waters Corporation, United States Published on June 05, 2025 Contact Sales Abstract PROteolysis TArgeting…

Application Note Rapid, High Sensitivity Quantification of a Proteolysis Targeting Chimera, PROTAC, in Rat Plasma From a Microsampling DMPK Study Using UPLC-MS/MS Robert S. Plumb Waters Corporation Abstract Proteolysis targeting chimeras are bifunctional molecules with two molecular entities connected by…

Application Note A Streamlined Workflow for Quantitative Bioanalysis using waters_connect for Quantitation Software: A Case Study Using Gefitinib Robert Plumb Waters Corporation, United States Published on November 20, 2025 Abstract Preclinical and early human drug metabolism and pharmacokinetics (DMPK) studies…