Investigation of Oligonucleotide Deamination Using High Resolution Mass Spectrometry

Application Note Quantifying Oligonucleotide Deamination with Multi-Reflecting Time-of-Flight Mass Spectrometry Jo-Anne Riley, Jonathan Fox, Laetitia Denbigh, Scott Berger, Nick Pittman, Ying Qing Yu Waters Corporation, United States Published on September 09, 2025 Abstract In this study, the identification and quantification…

A WORKFLOW FOR PURITY DETERMINATION, INTACT MASS MEASUREMENT AND MS/MS SEQUENCING OF OLIGONUCLEOTIDE IMPURITIES DETECTED IN SYNTHETIC OLIGOS Catalin Doneanu1, Jonathan Fox2, Brad J. Williams1, Chris Knowles3, Scott Berger1and Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation,…

Application note | 001398 Biopharma Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform Application benefits Authors Hao Yang , Keeley Murphy , Yi Zhang , 1 2 3 • Comprehensive characterization of oligonucleotides and their impurities…

AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES Catalin Doneanu1, Chris Knowles2, Mathew Gorton3, Joseph Fredette1, Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Newcastle upon Tyne, United Kingdom…