Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform

Streamlining workflow from characterization to monitoring of therapeutic oligonucleotides impurities across IPRP-LC-HRAM-MS platforms Hao Yang1; Keeley Murphy2; Jennifer Sutton1; Ken Cook3;Cheryl Rhodick3; Tufail Bashir3; Angela Criscuolo3; Tabiwang N. Arrey4; Catharina Crone4; Min Du2 1Thermo Fisher Scientific, San Jose, CA, United…

Mass spectrometry Perfect fit Orbitrap Exploris MX mass detector Fit for purpose mass detection High-quality mass information offers significant advantages in accelerating biopharmaceutical late-stage development, commercialization, manufacturing, and quality control (QC). This information must be easily and reliably obtained, day…

APPLICATION NOTE 73789 Oligonucleotide mapping using BioPharma Finder software Authors: Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Min Du2 Thermo Fisher Scientific, San Jose, CA Thermo Fisher Scientific, Boston, MA 1 2 Keywords: Oligonucleotide, DNA, RNA, data dependent acquisition, tandem mass…

Method considerations for therapeutic ASO RNA analysis. Adducts and insource impurity generation Ken Cook1, Ulrik Mistarz1, Alexander Schwahn2, Fiona Rupprecht3 1 Thermo Fisher Scientific, Hemel Hempstead, United Kingdom, 2Thermo Fisher Scientific, Reinach, Switzerland, 3 Thermo Fisher Scientific, Dreieich, Germany Abstract…