Host Cell Protein Identification in Biopharmaceuticals Using Mass Spectrometry: An Iterative Acquisition Approach for Comprehensive Profiling

Application Note Biotherapeutics and Biosimilars Host Cell Protein Analysis Using Agilent AssayMAP Bravo and 6545XT AdvanceBio LC/Q-TOF Authors Linfeng Wu, Shuai Wu and Te-Wei Chu Agilent Technologies, Inc., Santa Clara, CA, USA Introduction Use of biopharmaceuticals such as monoclonal antibodies…

APPLICATION NOTE 74109 Comprehensive identification and label-free quantitation of host cell protein contaminants using BioPharma Finder 4.1 software Authors: Silvia Millán-Martín,1 Sara Carillo,1 Jonathan Bones1, Jennifer Sutton2 National Institute for Bioprocessing Research and Training (NIBRT), Dublin, Ireland 1 2 Thermo…

Application Note Enhanced Host Cell Protein Identification and Quantitation with Multi-Reflecting ToF LC-MS Jonathan Fox, Malcolm Anderson, Ying Qing Yu, Scott J Berger, Nick Pittman, Laetitia Denbigh Waters Corporation, United States Published on August 07, 2025 Abstract Host cell proteins…

[ APPLICATION NOTE ] A Comprehensive Approach for HCP Identification, Quantification, and Monitoring Based on a Single Dimension (1D) LC Separation Catalin Doneanu, 1 Sarah Lennon, 2 Malcolm Anderson, 2 Ian Reah, 3 Mal Ross, 3 Steven Anderson, 3 Ian…