Advanced Monoclonal Antibody Peptide Mapping Using Multi-Reflecting TOF MS Technology

Application Note Enhanced Host Cell Protein Identification and Quantitation with Multi-Reflecting ToF LC-MS Jonathan Fox, Malcolm Anderson, Ying Qing Yu, Scott J Berger, Nick Pittman, Laetitia Denbigh Waters Corporation, United States Published on August 07, 2025 Abstract Host cell proteins…

Application Note Multi-Reflecting Time of Flight-MS: A Novel Technology for In-depth mAb Subunit Characterization Jonathan Fox, Ying Qing Yu, Scott J. Berger, Nick Pittman Waters Corporation Application Brief This is an Application Brief and does not contain a detailed Experimental…

Application Note Advancing ADC Characterization: SECBased Native DAR and Drug Distribution Analysis Using Multi-Reflecting TOF-MS and INTACT Mass Application Jonathan Fox, Scott J Berger, Laetitia Denbigh, Sam Ippoliti Waters Corporation, United States Published on December 24, 2025 Abstract This technology…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…