Digesta Ex Machina: Automating Sample Preparation for Oligo Mapping With Rapizyme™ MC1 and Cusativin on Andrew+™ Robot

Application Note Tunable Digestions of RNA Using RapiZyme™ RNases to Confirm Sequence and Map Modifications Balasubrahmanyam Addepalli, Tatiana Johnston, Christian Reidy, Matthew A. Lauber Waters Corporation Abstract RNA therapeutics such as sgRNA and mRNA are important modalities for Gene Therapy…

Application Note Sequence Mapping of sgRNA Digests: Leveraging Xevo™ MRT Mass Spectrometer Performance and Streamlining Data Analysis with MAP Sequence 2.0 Catalin Doneanu, Alexandre F Gomes, Tatiana Johnston, Chris Preston, Matt Gorton, Bala Addepalli, Scott Berger, Ying Qing Yu Waters…

Application Note RNA Digestion Product Mapping Using an Integrated UPLC-MS and Informatics Workflow Catalin E. Doneanu, Chris Preston, Matt Gorton, Tatiana Johnson, Bala Addepalli, Ying Qing Yu Waters Corporation Abstract LC-MS analysis is an indispensable tool for single-guide RNA (sgRNA)…

Application Note Oligo Mapping of sgRNA Digests: Leveraging Xevo MRT Mass Spectrometer Performance and Streamlining Data Analysis Catalin Doneanu, Alexandre F Gomes, Tatiana Johnston, Chris Preston, Matt Gorton, Bala Addepalli, Scott Berger, Ying Qing Yu Waters Corporation, Milford, MA, United…