Monitoring Protein Deamidation by Cation-Exchange Chromatography

User Manual ProPac WCX-10 and SCX-10 031410 Revision 08 • October 2015 For Research Use Only. Not for use in diagnostic procedures. Product Manual for ProPac WCX-10 and ProPac SCX-10 Page 2 of 30 PRODUCT MANUAL FOR PROPAC® WCX-10 AND…

Application Note 127 Monitoring Monoclonal Antibody Heterogeneity by Cation-Exchange Chromatography INTRODUCTION During the development and production of therapeutic proteins, characterization of structural variants is a critical challenge. C-terminal processing of lysine residues on the heavy chain of monoclonal antibodies (MAbs)…

Michael Menz, Carsten Paul, Evert-Jan Sneekes Thermo Fisher Scientific, Germering, Germany Appli cat i on Br i e f 7 1 8 1 1 High Salt Gradient Analysis of Post-Translational Modifications Deamidation Monitoring Key Words Biopharma, biopharmaceuticals, Vanquish Flex UHPLC,…

Agilent Biocolumns Charge Variant Analysis Application Compendium Contents Background 2 Getting Started 3 How to Guide - Ion-Exchange Chromatography for Biomolecule Analysis - 5991-3775EN 4 Featured Application Notes 22 Convenient Customization of Your Cation Exchange Analysis 5994-3257EN  22 How…