Automated, Online Second Virial Coefficient (A2) Measurements

Calypso Application Note: Automated 2nd virial coefficients with Calypso The 2nd virial coefficient (A2) is a general measure of weak, non‐specific protein‐ protein interactions. Characterization of A2 vs. buffer properties, e.g. ionic strength or pH, is useful in optimizing a…

Protein Solutions™ Rapid, Automated Molecular Characterization Using a Binary HPLC pump A standard binary pump, such as those used for HPLC systems, may be used to prepare, mix, and inject multiple sample concentrations required for a standard Zimm plot. Continuous…

A P P L I C AT I O N N O T E AN3009: Characterization of self-associating antibody solutions at high concentrations with CG-MALS Sophia Kenrick, Ph.D. and Daniel Some, Ph.D., Waters | Wyatt Technology Summary The characterization of…

PEG-Protein Interactions for Stable Formulations Studied by CG-MALS Daniel Some and Sophia Kenrick, Wyatt Technology Corp., Santa Barbara, CA 93117 1. Background Many therapeutic proteins such as antibodies exhibit non-specific self-association at concentrations > 10 mg/mL typical of final drug-product…