Characterization of self-associating antibody solutions at high concentrations with CG-MALS

PEG-Protein Interactions for Stable Formulations Studied by CG-MALS Daniel Some and Sophia Kenrick, Wyatt Technology Corp., Santa Barbara, CA 93117 1. Background Many therapeutic proteins such as antibodies exhibit non-specific self-association at concentrations > 10 mg/mL typical of final drug-product…

AN3002: Understanding antibody and viral glycoprotein interactions using CG-MALS Kathryn M. Hastie, Ph.D., and Erica Ollmann Saphire, Ph.D., The Scripps Research Institute Summary Viral glycoproteins are often the only antigen found on the viral surface and, as such, are key…

A P P L I C AT I O N N O T E AN3008: Metacomplex Formation & Binding Affinity of Multivalent Binding Partners Sophia Kenrick, Ph.D. and Dan Some, Ph.D., Wyatt Technology Summary Multivalent binding plays a crucial role…

Volume 27, Number 2 Technical Article by Daniel Some, Elizabeth Hitchner, and Julia Ferullo Characterizing Protein–Protein Interactions via Static Light Scattering: Nonspecific Interactions T he quantitative characterization of nonspecific protein– protein interactions is essential in understanding basic biomolecular function as…