Increased LC/MS Sensitivity for Methylmalonic Acid Using Mixed-Mode Reversed-Phase/Anion-Exchange Chromatography and MaxPeak Premier Columns

Application Note Improved Analytical Sensitivity and Chromatographic Peak Shape for the Quantification of TCA Cycle Analytes in Human Plasma using the ACQUITY PREMIER System Solution Kerri M. Smith, Paul D. Rainville Waters Corporation For research use only. Not for use…

Application Note Improving Sensitivity and Analytical Method Greenness using MaxPeak™ Premier 1.0 mm Internal Diameter Columns Kenneth Berthelette, Chris Collins, Thomas H. Walter Waters Corporation, United States Published on February 16, 2026 Abstract Sensitivity is an important aspect of metabolomics…

Ion Pairing Free Mixed-Mode Chromatography for the Separation and Measurement of TCA Cycle Metabolites in Urine Samples of Breast Cancer Patients Kerri M Smith, Giorgis Isaac, Suraj Dhungana and Paul D. Rainville Waters Corporation, Milford MA RESULTS and DISCUSSION Additional…

Improving sensitivity for the quantification of TCA cycle analytes in human plasma by the ACQUITY™ Premier system solution Kerri M Smith, Paul. D Rainville Waters Corporation, Milford, MA, USA LC System: ACQUITY™ Premier LC MS: XEVO TQ-Smicro, ESI negative Column:…