Improved Analytical Sensitivity and Chromatographic Peak Shape for the Quantification of TCA Cycle Analytes in Human Plasma using the ACQUITY PREMIER System Solution

Improving sensitivity for the quantification of TCA cycle analytes in human plasma by the ACQUITY™ Premier system solution Kerri M Smith, Paul. D Rainville Waters Corporation, Milford, MA, USA LC System: ACQUITY™ Premier LC MS: XEVO TQ-Smicro, ESI negative Column:…

Ion Pairing Free Mixed-Mode Chromatography for the Separation and Measurement of TCA Cycle Metabolites in Urine Samples of Breast Cancer Patients Kerri M Smith, Giorgis Isaac, Suraj Dhungana and Paul D. Rainville Waters Corporation, Milford MA RESULTS and DISCUSSION Additional…

MaxPeak Premier Columns Small Molecule Application Notebook CONTENTS Introduction Non-Specific Adsorption: Unwanted Interactions................................................................................... 3 How Do Scientists Solve This Problem Today?......................................................................................... 4 Precision Chemistry for Particles and Surfaces........................................................................................ 5 Fundamentals Waters™ Premier Standards to Investigate the Inertness of Chromatographic Systems....................................................................................................................................7…

Application Note Improving Sensitivity and Analytical Method Greenness using MaxPeak™ Premier 1.0 mm Internal Diameter Columns Kenneth Berthelette, Chris Collins, Thomas H. Walter Waters Corporation, United States Published on February 16, 2026 Abstract Sensitivity is an important aspect of metabolomics…