MULTIDIMENSIONAL LC-MS PLATFORMS FOR STRUCTURE-FUNCTION CHARACTERIZATION OF THERAPEUTIC ANTIBODIES

Application Note Biopharma/Pharma Determination of Multiple Attributes of Monoclonal Antibodies Simultaneous and parallel multi-attribute analysis using 3D-LC/MS with 2D multimethod option mAb SEC Size variants Protein A CEX LC/MS mAb Titer Charge variants Mol wt (MW) AA sequence PTM Cell…

Application Note Pharma & Biopharma Multi-Attribute Analysis of Monoclonal Antibodies Using the Agilent InfinityLab 2D-LC Solution and Q-TOF MS Authors Gerd Vanhoenacker, Isabel Vandenheede, Pat Sandra, and Koen Sandra Research Institute for Chromatography (RIC) Kortrijk, Belgium Sonja Krieger, Sonja Schneider,…

Biopharma Compendium Accelerate Your CQA Efficiency and Approach it with Multi-Attribute Methodology Breakthroughs to Increase the Efficiency of Critical Quality Attribute (CQA) Testing and Allow for a Multi- Attribute Method (MAM) Production of therapeutic monoclonal antibodies (mAbs) relies on living…

Consumables Workflow Ordering Guide Multi Dimensional HPLC Separation of Monoclonal Antibody Mixtures from Cell Culture Supernatants Therapeutic monoclonal antibodies (mAbs) come with structural complexity highly demanding towards analytics. Combining multiple analytical techniques on a system enables simultaneous multi-attribute analysis (MAA)…