Multi Dimensional HPLC Separation of Monoclonal Antibody Mixtures from Cell Culture Supernatants

Consumables Workflow Ordering Guide Improving the Quality of Antibody Drug Conjugates by Orthogonal Analytical Methods Antibody Drug Conjugates Antibody-drug conjugates (ADCs) represent a new generation of targeted biotherapeutics that make up a rapidly growing segment of the drug discovery pipeline.…

Consumables Workflow Ordering Guide Analyzing Monoclonal Antibody (mAbs) and mAb-Derived Therapeutics Using Native SEC-MS The quantitation of aggregates is of particular concern for protein-based-therapies given their potential effect on efficacy and immunogenicity. Size exclusion chromatography (SEC) combined with UV detection…

Consumables Workflow Ordering Guide mAb Charge Variant Analysis by Weak Cation Exchange (WCX) Chromatography Monoclonal antibodies (mAbs) are a prominent biotherapeutic that are produced by most major pharmaceutical companies. mAbs are about 150,000 Daltons and have several modifications that add…

Consumables Workflow Ordering Guide Analyzing Monoclonal Antibody (mAb) Fragments and Dimers Using Size Exclusion Chromatography (SEC) Low molecular weight (LMW) fragments and high molecular weight (HMW) dimers and aggregates can be formed from biotherapeutic proteins during drug development, storage, shipment,…