Development of an online two-dimensional SEC-UV-RPLC-MS method for the multi-attribute characterization of adeno-associated virus products

[ APPLICATION NOTE ] Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS Ximo Zhang, Stephan Koza, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ INTRODUCTION An optimized LC-MS solution for…

Application Note Pharma & Biopharma Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF Authors Wendi A. Hale and Christopher M. Colangelo Agilent Technologies, Inc., Lexington, MA, USA Roy Hegedus and Norman Garceau Lake Pharma, Worcester, MA, USA…

Developing the analytics and analytical workflows supporting the analysis of the next generation of biotherapeutic and gene therapies. Scott J. Berger, Ph.D. and Ximo Zhang, Ph.D. Waters Lunch Seminar Tuesday January 28, 2020 WCBP 2020 Diamond Program Partner ©2020 Waters…

Advanced Therapeutic Medicinal Products: Adeno-associated Virus (AAV) The Promise of Viral Vector Gene Therapy using AAV 7000 Monogenic Diseases 20 of 22 4 Years Children with spinal muscular atrophy (SMA) given the ability to thrive with Zolgensma® (AAV) at 91%…