Developing the analytics and analytical workflows supporting the analysis of the next generation of biotherapeutic and gene therapies

[ APPLICATION NOTE ] Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS Ximo Zhang, Stephan Koza, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ INTRODUCTION An optimized LC-MS solution for…

Analytical solutions to accelerate your AAV gene therapy Gene therapy holds great promise for a wide range of diseases, including cancers, cardiovascular diseases and thousands of rare hereditary diseases caused by gene mutations. HE ALTHY GENE VIR AL VECTOR WITH…

Advanced Therapeutic Medicinal Products: Adeno-associated Virus (AAV) The Promise of Viral Vector Gene Therapy using AAV 7000 Monogenic Diseases 20 of 22 4 Years Children with spinal muscular atrophy (SMA) given the ability to thrive with Zolgensma® (AAV) at 91%…

Development of an online two-dimensional SEC-UV-RPLC-MS method for the multi-attribute characterization of adeno-associated virus products MULTIDIMENSIONAL CHROMATOGRAPHY WORKSHOP 4th February 2025 Megane Aebischer [email protected] Introduction Genetic disease Defective DNA Defective protein Introduction 2D-LC workflow Applications Conclusion 2 [email protected] Adeno-associated virus…