Characterization and quantification of lipid nanoparticle components and their impurities/degradants using an LC-HRAM MS platform

Characterization and quantification of lipid nanoparticle components and their degradants in vivo using an LC-HRAM MS platform Reiko Kiyonami1, Ralf Tautenhahn1, Min Du2, Sinae Lee3, Evgenia Verovskaya3, Jason Potter3, 1Thermo Fisher Scientific, San Jose, CA; 2Thermo Fisher Scientific, Cambridge, MA,…

Application note | 001343 Biopharma Applying UHPLC-HRAM MS technology to characterize and quantify lipid components in vivo to support new LNP development Authors Application benefits Reiko Kiyonami, Sinae Lee, Koshi 1 2 • A sensitive and robust LC-MS based platform…

Biopharmaceuticals Analytical solutions for mRNA vaccines and therapeutics Table of contents mRNA vaccines and therapeutics mRNA characterization Lipid nanoparticle characterization Critical quality attributes of mRNA therapeutics Direct mRNA sequence confirmation LNP composition analysis by LC-CAD Optimize impurity analysis with ease…

Lipid Nanoparticle Impurity Monitoring Using Single Quadrupole Mass Detection for Regulated Environments Authors: Duanduan Han, Kellen DeLaney, Robert E. Birdsall, Ying Qing Yu Affiliation: Waters Corporation, Milford, MA Results Introduction Lipid Nanoparticles UV 3 AU 2 Cholesterol • Important for…