Characterization and quantification of lipid nanoparticle components and their degradants in vivo using an LC-HRAM MS platform

Application note | 000464 Mass Spectrometry Characterization and quantification of lipid nanoparticle components and their impurities/degradants using an LC-HRAM MS platform Authors Application benefits Reiko Kiyonami , Ralf Tautenhahn , 1 1 • Confident lipid nanoparticle (LNP) component confirmation through…

Application note | 001343 Biopharma Applying UHPLC-HRAM MS technology to characterize and quantify lipid components in vivo to support new LNP development Authors Application benefits Reiko Kiyonami, Sinae Lee, Koshi 1 2 • A sensitive and robust LC-MS based platform…

Application Note Rapid Analysis of Lipid Nanoparticle Components Using BioAccord LC-MS System Giorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. Plumb Waters Corporation Abstract The recent success of mRNA vaccines for COVID-19 is in part…

Biopharmaceuticals Analytical solutions for mRNA vaccines and therapeutics Table of contents mRNA vaccines and therapeutics mRNA characterization Lipid nanoparticle characterization Critical quality attributes of mRNA therapeutics Direct mRNA sequence confirmation LNP composition analysis by LC-CAD Optimize impurity analysis with ease…