Process Monitoring of Monoclonal Antibody Subunits for Fast, Critical Quality Attribute Monitoring Using the ACQUITY QDa Detector

[ APPLICATION NOTE ] Process Monitoring of Monoclonal Antibody Subunits for Fast, Critical Quality Attribute Monitoring Using the ACQUITY QDa Detector Brooke M. Koshel, Robert E. Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…

Application Note Pharma & Biopharma Critical Quality Attribute Monitoring of mAbs at the Intact and Subunit Levels Using a Cost-Effective, Simple and Robust LC/MS Solution Authors Linfeng Wu, Lisa Zang, and Guannan Li Agilent Technologies, Inc. Abstract Recombinant monoclonal antibodies…

Application Note Establishment of a Robust mAb Subunit Product Quality Attribute Monitoring Method Suitable for Development, Process Monitoring, and QC Release Samantha Ippoliti, Ying Qing Yu, Nilini Ranbaduge, Weibin Chen Waters Corporation Abstract This application note presents a subunit MAM…