Electron Capture Dissociation in Combination With High Performance Cyclic Ion Mobility Separation for Detailed Protein Studies

EXPANDING NATIVE MASS SPECTROMETRY CAPABILITIES FOR SOLUBLE AND MEMBRANE PROTEINS USING A QUADRUPOLE-ION MOBILITY-TIME-OF-FLIGHT MASS SPECTROMETRY SYSTEM Brad Williams1, Dale A. Cooper-Shepherd2, Mario Hensen3, Kleitos Sokratos3, Jonathan T.S. Hopper3, and James I. Langridge2 1. Waters Corporation, 34 Maple Drive, Milford,…

Increasing sensitivity in peptide-level studies; Cyclic ECD product ions Dale A. Cooper-Shepherd1, Isabella A. Jones1, Emma Marsden-Edwards1, Ramin Rabbani2 1Waters Corporation, Wilmslow, Cheshire, UK; 2Waters Corporation, Milford, MA, USA IMS-enabled Wideband Enhancement of CID and INTRODUCTION OPTIMIZATION OF CYCLIC IMS…

BOOSTING SENSITIVITY IN TOP-DOWN PROTEIN STUDIES USING CYCLIC IMS-ENABLED WIDEBAND ENHANCEMENT Catherine Tremblay1, Dale A. Cooper-Shepherd2, Isabella A. Jones2, Emma Marsden-Edwards2 1Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, Cheshire, UK • Top-down protein analysis relies on tandem MS (MSMS)…

Subunit Level Top-down ECD Characterization of Biotherapeutic Proteins: Improving Mass Spectral Clarity with Fragment Ion Level Ion Mobility Henry Shion1, Brad J. Williams1, Dale Cooper-Shepherd2, and Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2 Waters Corporation, Wilmslow, Manchester,…