A novel approach for multiple PQAs monitoring of mAbs from bioreactors using 2D-LC-MS

Application note | 003310 Biopharma Monitoring of multiple quality attributes of intact monoclonal antibodies from bioreactors by switchable 2D-LC-MS Authors Application benefits Maria Grübner , Kai Scheffler , 1 1 • Heart-cut 2D-LC with protein A affinity chromatography (ProA) of…

Process Analytics A switchable 2D-LC platform in PAT: routine UV monitoring or MS-based characterization of mAb PQAs directly from the bioreactor Maria Grübnera, Runsheng Zhenga, Alexander Schwahnb, Ken Cookc, Thermo Fisher Scientific, a Germering (Germany), b Reinach (Switzerland), c Hemel…

Application note | 004276 Biopharma Monitoring monoclonal antibody bioproduction processes with 2D-LC-UV Author Application benefits Maria Grübner, Thermo Fisher Scientific, • Heart-cut 2D-LC with protein A affinity chromatography (ProA) of cell culture samples enables titer determination and purification for subsequent…

Biologics quality control Affinity titer analysis to enable scalable mAb and bispecific production Kelly Flook1, Julia Bulmahn2, and Ross Pritchett3 1 Thermo Fisher Scientific, Pleasanton, CA, 94566, 2 Thermo Fisher Scientific, Grand Island, NY, 14072, 3 Thermo Fisher Scientific, Carlsbad,…