Metabolite Profiling of the Antisense Oligonucleotide Tofersen Using UHPLC-HRAM mass spectrometry

Measurement of Oligonucleotide Impurities/ LCMS-9030 Application News Measurement of Oligonucleotide Impurities Using Shimadzu Nexera XS Inert Coupled To LCMS-9030 QTOF Shannie Tay1, Derrick Tan1, Celine Sim2 1 Shimadzu Asia Pacific, Singapore 2 Nanyang Technological University, Singapore User Benefits  End-to-end…

Pharma and biopharma Accelerating metabolite identification with mass spectrometry Contents 1. Why is metabolite identification critical for drug discovery? Next page 3 1.1. How to perform metabolite identification in drug discovery? 5 1.2. Why is HRAM MS advantageous in metabolite…

Fast acquisition of DDA-MS/MS of oligonucleotides and the novel spectral merging algorithm for better assignment of Kosuke Uchiyama , Yoshihiro Kunimura , Simon Ashton , Richard Price , Helen Jose , Atsuhiko Toyama , Neil Loftus sequence information Shimadzu Corporation,…

White paper | 002154 Pharma Increased confidence in drug metabolite identification through intelligent data acquisition strategies and multiple fragmentation techniques on the Orbitrap Tribrid MS platform Authors Overview Sven Hackbusch¹, Kate Comstock¹, • The LC/MS analysis of drug metabolites relies…