Capillary flow ion pair reversed-phase separation for very sensitive oligonucleotide LC-HRMS analysis and characterisation

Method considerations for therapeutic ASO RNA analysis. Adducts and insource impurity generation Ken Cook1, Ulrik Mistarz1, Alexander Schwahn2, Fiona Rupprecht3 1 Thermo Fisher Scientific, Hemel Hempstead, United Kingdom, 2Thermo Fisher Scientific, Reinach, Switzerland, 3 Thermo Fisher Scientific, Dreieich, Germany Abstract…

Streamlining workflow from characterization to monitoring of therapeutic oligonucleotides impurities across IPRP-LC-HRAM-MS platforms Hao Yang1; Keeley Murphy2; Jennifer Sutton1; Ken Cook3;Cheryl Rhodick3; Tufail Bashir3; Angela Criscuolo3; Tabiwang N. Arrey4; Catharina Crone4; Min Du2 1Thermo Fisher Scientific, San Jose, CA, United…

Oligonucleotide analysis Detailed study into ASO impurity analysis, lessons learned, and myths dispelled while moving to compliant platform methods Ulrik H. Mistarz1, Marcus Hoffmann2, Heiko Herrmann2, Richard Law3, Alexander Schwahn4, Ken Cook5 1Thermo Fisher Scientific, Denmark, 2Thermo Fisher Scientific, Germany,…

Oligonucleotide analysis Green ion pair and HFIP free method for ASO RNA analysis with GLP compliant automated data handling Ulrik H. Mistarz1, Marcus Hoffmann2, Heiko Herrmann2, Alexander Schwahn3, Simon Szwandt4 Ken Cook4 1Thermo Fisher Scientific, Denmark, 2Thermo Fisher Scientific, Germany,…