Ultra-sensitive quantitation of therapeutic oligonucleotide in human plasma by a high resolution accurate mass Orbitrap mass spectrometer

Application note | 002679 Biopharma Sensitive quantitation of antisense oligonucleotides in plasma using high-resolution, accurate-mass (HRAM) mass spectrometry Authors Application benefits Hao Yang , Xuguang Yan , Moo-Young Kim , Sensitive and reproducible quantitation of antisense oligonucleotides with human Jon…

Application note | 002568 Biopharma Sensitive LC-MS/MS quantitation of antisense oligonucleotides in plasma using the TSQ Altis Plus mass spectrometer Application benefits Authors Hao Yang , Xuguang Yan , Moo-Young Kim , Sensitive and reproducible quantitation of ASOs with human…

T1530 ‐09‐54 Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance Suma Veeramachineni, Mark D Wrona Waters Corporation, Milford, MA CONTACT INFORMATION: [email protected]; [email protected] PURPOSE RESULT(S) Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes…

TECHNICAL NOTE 66058 Quantification of 15 tricyclic antidepressants in human plasma or serum by LC-HRAM-MS for clinical research Authors: Gaëtan Renoulin1, Mariana Barcenas1, Claudio De Nardi2 Thermo Fisher Scientific, Les Ulis, France 1 Thermo Fisher Scientific, Reinach, Switzerland 2 Keywords:…