Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance

English Denmark | Application Note Sensitive Bioanalysis of Antisense Oligonucleotides of Various Lengths and Modifications Suma Veeramachineni, Mark D. Wrona Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract This application brief demonstrates…

Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer Suma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MA Introduction Results Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes has been of…

Application note | 002679 Biopharma Sensitive quantitation of antisense oligonucleotides in plasma using high-resolution, accurate-mass (HRAM) mass spectrometry Authors Application benefits Hao Yang , Xuguang Yan , Moo-Young Kim , Sensitive and reproducible quantitation of antisense oligonucleotides with human Jon…

Application note | 002568 Biopharma Sensitive LC-MS/MS quantitation of antisense oligonucleotides in plasma using the TSQ Altis Plus mass spectrometer Application benefits Authors Hao Yang , Xuguang Yan , Moo-Young Kim , Sensitive and reproducible quantitation of ASOs with human…