High Resolution Mass Spectrometry and LC-UV Data Streams Applied to Characterizing Oligonucleotide Impurities

Impurity Profiling and Characterization of Therapeutic Oligonucleotides using Nominal Mass Spectrometry on a Single Quadrupole LC-UV-MS system Risa Suzuki1, 3, Kosuke Uchiyama1, Noriko Kato1, Simon Ashton2, Neil Loftus2, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu…

Single Quadrupole Mass Spectrometry Quick Workflows Specified to Oligonucleotides Screening Kosuke Uchiyama1, Noriko Kato1, Qiuyi Wang1, Simon Ashton2, Neil Loftus2, Risa Suzuki1, 3, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu Scientific Instruments, Inc., Columbia, Maryland…

WP 579 Rapid monitoring of the purification process of oligonucleotide impurities using a benchtop MALDI-TOF MS system Takashi Nishikaze1, Kosuke Uchiyama1, Risa Suzuki1, Junji Kawakami2, Takao Inoue3, Satoshi Obika4, and Yoshihiro Hayakawa1 (1) Shimadzu Corporation, Kyoto, Japan; (2) Konan University,…

Integrated Data Analysis of Oligonucleotide Therapeutics Using LC-MS, LC-MS/MS and MALDI techniques 1 2 2 3 3 3 3 Nishi Rochelle ; Neil J Loftus ; Simon Ashton ; Kosuke Uchiyama ; Risa Suzuki ; Takashi Nishikaze ; Yuka Fujito…