Single Quadrupole Mass Spectrometry Quick Workflows Specified to Oligonucleotides Screening

Impurity Profiling and Characterization of Therapeutic Oligonucleotides using Nominal Mass Spectrometry on a Single Quadrupole LC-UV-MS system Risa Suzuki1, 3, Kosuke Uchiyama1, Noriko Kato1, Simon Ashton2, Neil Loftus2, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu…

A Software Workflow Using Wide Mass Range Single Quadrupole Mass Spectrometry Data Stream Applied to Oligonucleotides Confirmation Risa Suzuki1, 2, Kosuke Uchiyama2, Noriko Kato2, Yuka Fujito2, Jeffery Dahl1, Simon Ashton3, Neil Loftus3, Atsuhiko Toyama2, 4 1Shimadzu Scientific Instruments, Inc., Columbia,…

Integrated Data Analysis of Oligonucleotide Therapeutics Using LC-MS, LC-MS/MS and MALDI techniques 1 2 2 3 3 3 3 Nishi Rochelle ; Neil J Loftus ; Simon Ashton ; Kosuke Uchiyama ; Risa Suzuki ; Takashi Nishikaze ; Yuka Fujito…

Application Note A Xevo™ G3-based Workflow for Purity Determination, Intact Mass Measurement, and MS/MS Sequencing of Impurities Detected in Synthetic Oligonucleotides Catalin E. Doneanu, Jonathan Fox, Brad J. Williams, Chris Knowles, Ying Qing Yu Waters Corporation Abstract This study evaluates…