ASGTC: mRNA/LNP Multiattribute Quantitation of Payload(s), Size and Heterogeneity With Size Exclusion Chromatography Coupled to Multiangle Light Scattering

Application Note Deformulating Size Exclusion Chromatography for LNP Payload Quantitation Mateusz Imiolek, Szabolcs Fekete, Matthew A. Lauber Waters Corporation Abstract This application note discusses the use of a GTxResolve™ Premier BEH™ SEC 450 Å Column for the online deformulation of…

AN2615: Multi-attribute quantification of LNP-mRNA therapeutics by FFF-MALS and DLS Martin Kurnik, Ph.D., Wyatt Technology, LLC Summary Introduction Bringing effective and safe lipid nanoparticle-formulated mRNA therapeutics to market requires quantitation of multiple quality attributes throughout development, manufacturing, and quality control.…

Application Note Efficient Profiling of Lipid Nanoparticle Formulations Using Waters GTxResolve 2000 Å SEC Column, MaxPeak Premier 3 µm Abraham Samuel Finny, Lavelay Kizekai, Christian Reidy, Mandana Fasth, Balasubrahmanyam Addepalli, Matthew Lauber Waters Corporation, United States Published on May 05,…

CHARACTERIZING LIPID NANOPARTICLE VACCINES USING CDMS AND FFF-MALS: A MULTI-DIMENSIONAL APPROACH Rebecca J. D'Esposito1; Erin McAllister1; Martin Kurnik2; Sophia Kenrick2; Ying Qing Yu1; Michelle Chen2 1Waters Corporation, Milford, MA; 2Waters Corporation, Goleta, CA Methods Methods Charge Detection Mass Spectrometry: Xevo…