Estimating protein partitioning in multicomponent aqueous two-phase extraction based on CG-MALS measurements

Volume 27, Number 2 Technical Article by Daniel Some, Elizabeth Hitchner, and Julia Ferullo Characterizing Protein–Protein Interactions via Static Light Scattering: Nonspecific Interactions T he quantitative characterization of nonspecific protein– protein interactions is essential in understanding basic biomolecular function as…

PEG-Protein Interactions for Stable Formulations Studied by CG-MALS Daniel Some and Sophia Kenrick, Wyatt Technology Corp., Santa Barbara, CA 93117 1. Background Many therapeutic proteins such as antibodies exhibit non-specific self-association at concentrations > 10 mg/mL typical of final drug-product…

A P P L I C AT I O N N O T E AN3009: Characterization of self-associating antibody solutions at high concentrations with CG-MALS Sophia Kenrick, Ph.D. and Daniel Some, Ph.D., Waters | Wyatt Technology Summary The characterization of…

AN3002: Understanding antibody and viral glycoprotein interactions using CG-MALS Kathryn M. Hastie, Ph.D., and Erica Ollmann Saphire, Ph.D., The Scripps Research Institute Summary Viral glycoproteins are often the only antigen found on the viral surface and, as such, are key…