Rapid mAb Charge Variant Analysis with 20 mm Cation Exchange Columns

[ APPLICATION NOTE ] Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column Hua Yang, Bill Warren, and Stephan Koza Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Method development parameters for cation Charge heterogeneity…

[ APPLICATION NOTE ] Optimizing LC-MS Separations of mAbs using a BioResolve SCX mAb Column and IonHance CX-MS pH Concentrates Andrew Schmudlach, Samantha Ippoliti, Qi Wang, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION A novel…

[ APPLICATION NOTE ] Development of pH Gradient Mobile Phase Concentrates for Robust, High Resolution mAb Charge Variant Analysis Qi Wang, Susan C. Rzewuski, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Platform method…

DESIGNING A NEW PARTICLE TECHNOLOGY AND PH GRADIENT MOBILE PHASE CONCENTRATES FOR ROBUST, HIGH RESOLUTION CHARGE VARIANT ANALYSIS OF MABS Paula Orens, Matthew A. Lauber, Qi Wang, Susan C. Rzewuski, Hua Yang, Stephan Koza, Mingcheng Xu, Mike F. Morris, Justin…