ADVANCING ANALYTICAL APPROACHES FOR ROBUST EVALUATION OF LARGE MOLECULE BIOLOGICS USING LIQUID CHROMATOGRAPHY

Application Note Extended Analysis of mAbs Using IonExchange Chromatography on the Alliance™ iS Bio HPLC System Corey Reed, Paula Hong Waters Corporation Abstract Large molecule biologics continue to be a major focus in the pharmaceutical market. These biopharmaceutical drugs require…

Application Note Method Transfer of Size-Exclusion and IonExchange Methods for Monoclonal Antibody Analysis from HPLC to the Arc Premier System Brooke M. Koshel, David Dao, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Transferring methods between internal laboratories and…

Application Note Pharma & Biopharma Charge Variant and Aggregation Analysis of Innovator and Biosimilars of Rituximab Author Bian Yulan Global Solution Development Center, Global Laboratory Solution Sales (LSS) Marketing, Agilent Technologies Singapore (Sales) Pte. Ltd. Abstract Monoclonal antibodies are an…

Application Note Evaluation of Modern and Legacy HPLC Systems for the Size-Exclusion Analysis of Aggregation and Fragmentation in a Monoclonal Antibody Drug Corey E. Reed, Paula Hong Waters Corporation Abstract Size-exclusion chromatography is a widely used characterization technique for the…