Peptide Mapping for Biotherapeutics

Application Note Quick and Robust Sample Preparation for Tryptic Peptide Mapping With the PeptideWorks™ Kit Using Simple, Automatable Workflows Caitlin M. Hanna, Jonathan P. Danaceau, Stephan M. Koza, Steve Shiner, Mary Trudeau Waters Corporation Abstract Here, we present an automatable…

Application Note One Pot, Mildly Acidic Digestion Protocols for Peptide Mapping Using Lys-C and RapiZyme™ Trypsin Caitlin M. Hanna, Stephan M. Koza, Michael Zagieboylo, Steve Shiner Waters Corporation, United States Published on August 27, 2025 Abstract Peptide mapping of therapeutic…

Application Note Fast and Robust LC-UV-MS Based Peptide Mapping Using RapiZyme™ Trypsin and IonHance™ DFA Abraham S. Finny, Nick Zampa, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract Laborious and time-consuming peptide mapping protocols are made faster and more robust…

SIMPLE AND AUTOMATABLE SAMPLE PREPARATION FOR TRYPTIC PEPTIDE MAPPING WITH THE PEPTIDEWORKS KIT Caitlin M. Hanna, Hua Yang, Jonathan P. Danaceau, Stephan M. Koza, Steve Shiner, and Mary Trudeau Waters Corporation INTRODUCTION WORKFLOW & AUTOMATION DIGESTION COMPLETION Reliable day-to-day sample…