Novel real-time acquisition logic to prevent fragmentation of uninformative precursors

ASMS 2025 WP 097 prio-PASEF: Precision and Discovery in MetID Workflows Beixi Wang1; Xuejun Peng1; Jonathan R. Plante2; Reena G. Patel2; Kyle P. Mummau2; Elke S. Perloff2; Melvin Blaze2; Heiko Neuweger3; Erica Forsberg1 Results (a) prio-PASEF of Testosterone 1Bruker Scientific…

Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…

Using Parallel Accumulation Serial Fragmentation (PASEF) to speed up untargeted 4D lipidomics LC-MS/MS workflows The search for new and validated biomarkers is of particular interest in clinical areas like oncology [1, 2] or neurology [3]. As lipids play an important…

Investigating the increased lifespan in C. elegans daf-2 mutants by 4D-Lipidomics The small nematode Caenorhabditis elegans is one of the premier biomedical model organisms and employed in many aspects of basic and applied science Introduction Typical application areas for C.…