EAS: 2D Analysis of Protein Therapeutics and Amino Acid Excipients with Combined UV and Charged Aerosol Determination

D Poster Note 71 8 49 storage. The protein structure is susceptible to aggregation-prone phase transitions which are dependent on pH, temperature, and protein concentration. Stabilization of protein formulations can be enhanced through the addition of specific amino acids excipients…

Table of contents Summary Overview Excipient function Measurement Charged Aerosol Detector Universal detection Uniform response Working principles (U)HPLC Systems with CAD Columns choice Excipients overview Adjuvants Amino acids Carbohydrates Counterions Nonionic surfactants Polyethylene glycol Proteins and excipients HPLC-Charged Aerosol Detection…

Application of Charged Aerosol HPLC Detection in Biopharmaceutical Analysis Application of Charged Aerosol HPLC Detection Poster Note 71 8 0 3 formulated in UV-transparent excipients that must be detected and measured. In contrast to UV/Vis instruments, the Charged Aerosol Detector…

Charged Aerosol Detection 101 Dr. Alexander Schwahn European Sales Support Expert for Biopharma Industry Thermo Fisher Scientific, Reinach, Switzerland The world leader in serving science Outline • • • • • • 2 Introduction to charged aerosol detection (CAD) How…