Structure Characterization and Differentiation of Biosimilar and Reference Products Using Unique Combination of Complementary Fragmentation Mechanisms

Differentiate Minor Difference of Protein Structure in Biosimilar and Reference Products Using High-Resolution Orbitrap LC-MS/MS Zhiqi Hao1, David M. Horn,1 Shiaw-Lin Wu,2 Fan Zhang2 and Patrick Bennett1 1Thermo Fisher Scientific, San Jose, CA 2Barnett Institute, Northeastern University, Boston, MA Overview…

Thermo Scientific Glycan Analysis for Biotherapeutics Join the sweet revolution in biopharmaceuticals • Intact Glycoproteins • Glycopeptides • Free Glycans • Monosacccharides MEETING THE CHALLENGES of Glycan Characterization Biotherapeutic proteins, which include antibodies, are becoming the fastest growing category of…

Analytical solutions for biopharmaceutical characterization and control Your partner on every step of your journey Together we can address the challenges of biotherapeutic drug development Your molecules are complex Biotherapeutics such as monoclonal antibodies, biosimilars, antibody-drug conjugates, and nucleotide-based therapies…

Application Note Biotherapeutics and Biosimilars LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab Author Suresh Babu C.V. Agilent Technologies, Inc. Abstract The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products. This Application Note presents…