IMSIS: TOWARDS IN-VITRO DIAGNOSTIC IMAGING OF HEPA-RG SPHEROIDS BY DESI TANDEM QUADRUPOLE MS

TOWARDS IN-VITRO DIAGNOSTIC IMAGING OF HEPA-RG SPHEROIDS BY DESI TANDEM QUADRUPOLE MS Mark Towers1, Lisa Reid1, Alicia Rosell-Hidalgo2, Kirsten Headspith2 1 Waters Corporation, Wilmslow, Cheshire, UK 2 Cyprotex Ltd., Alderley Park, Cheshire, UK INTRODUCTION RESULTS AND DISCUSSION Dilution series Carbamazepine…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

TARGETED DESI IMAGING MS OF DRUG DISTRIBUTION AND DRUGINDUCED LIVER INJURY (DILI) METABOLITES FROM METHAPYRILENE IN THE MALE WISTAR RAT Anthony Midey,1 Emmanuelle Claude,2 Lisa Reid,2 Bindesh Shrestha,1 Steven K Lai,1 Ian D Wilson,3 Robert S Plumb,1 and Roy Martin1…

VISUALIZATION AND QUANTIFICATION OF DRUG/METABOLITES BY SENSITIVE AND FAST TARGETED DESI IMAGING ON TQ SYSTEM Emmanuelle Claude1, Ross Chawner1, Nathalie Delallée2, Stephanie Molez2, Gregory Nicolas2, Joanne Ballantyne1 1 Waters Corporation, Wilmslow, UK; 2Bioprojet, Saint Gregoire, France INTRODUCTION Mass spectrometry (MS)…