Molecular Weight and Sequence Confirmation of Oligonucleotides by LCMS-9030 Quadrupole Time-of-Flight (Q-TOF) Mass Spectrometer

MP-181 Molecular Weight and Sequence Confirmation of Oligonucleotides by LCMS-9030 Quadrupole Time-of-Flight (Q-TOF) Mass Spectrometer Xue Tang 1, Qiang Li2, Taohong Huang2 1 Shimadzu (China) Co., Ltd., Chengdu, China; 2 Shimadzu (China) Co., Ltd., Shanghai, China. 2-2. Sample preparation 1.…

WP 459 Qualification and Quantitation of Phosphorothioate Oligonucleotides Using a Quadrupole-Time-of-Flight Mass Spectrometer Noriko Kato, Yusuke Inohana, Tairo Ogura, Masaki Yamada, Toshiya Matsubara Shimadzu Corporation. 1, Nishinokyo-Kuwabaracho Nakagyo-ku, Kyoto 604–8511, Japan 3. Methods 1. Overview The purpose of this study…

C10G-E097 Oligonucleotide Therapeutics Solution Guide Types and Characteristics of Oligonucleotide Therapeutics Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases However, it is a practical problem that oligonucleotide therapeutics are degraded and excreted rapidly…

Application News MALDI-TOF Mass Spectrometry Analysis MALDI-8030 Liquid Chromatograph Mass Spectrometer LCMS™-9030 Analysis of Oligonucleotide Therapeutics using MALDI-8030 and LCMS-9030 Y.Yamazaki User Benefits  Confident characterization of oligonucleotides  Elemental formula confirmation by ESI-QTOF  Information of sequence by MALDI-ISD…