Qualification and Quantitation of Phosphorothioate Oligonucleotides Using a Quadrupole-Time-of-Flight Mass Spectrometer

C10G-E097 Oligonucleotide Therapeutics Solution Guide Types and Characteristics of Oligonucleotide Therapeutics Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases However, it is a practical problem that oligonucleotide therapeutics are degraded and excreted rapidly…

MALDI-TOF Mass Spectrometer: MALDI-8030 Sequence Analysis of Antisense Nucleic Acid Using a MALDI-8030 Benchtop MALDI-TOF Mass Spectrometer Application News Takashi Nishikaze User Benefits  MALDI-ISD enables simple and reliable sequencing of antisense nucleic acid.  There is no need to…

MALDI-DIT-MS Application News Oligonucleotide Analysis Using the Compact MALDImini™-1 MALDI Digital Ion Trap Mass Spectrometer Yuko Fukuyama User Benefits  Enables molecular weight analysis and sequence analysis of oligonucleotides, including modification sites.  MSn enables reliable end sequence analysis. …

Application News No. C215 LC-MS Determination of Molecular Mass and Quantification of Oligonucleotide Therapeutics Using Quadrupole Time-of-Flight Mass Spectrometer LCMS™-9030  Overview Oligonucleotide therapeutics are synthetic oligonucleotides that demonstrate their medical efficacy through binding to target genes or target proteins…