Polysorbate 80 profiling by HPLC with mass and charged aerosol detection

Application note | 003506 Pharma/Biopharma Characterization of polysorbate 80 in (bio)pharmaceuticals using HPLC-CAD Authors Application benefits Sylvia Grosse, Katherine Lovejoy • Characterize polysorbate 80 formulation through group-based quantitation applying the power value (PV) concept Germany • Identify the perfect linear…

Combining mass spectra, retention time modelling, and charged aerosol detection for unambiguous peak annotation and uniform-response quantitation in polysorbate profiling Denis A. Ispan1, Sara Carillo2, Jonathan Bones2, Ken Cook3, Frank Steiner1, Mauro De Pra1 1Thermo Fisher Scientific, Germering, Germany 2…

Simultaneous analysis of polysorbate 80 and poloxamer 188 in biopharmaceutical formulations using charged aerosol detector and single quadrupole mass spectrometer Xuepu Li 1, Sissi White 2, Mauro De Pra 3, Yu Cui 1, Min Du 2 1Thermo Fisher Scientific, Shanghai,…

Novel applications of multi-detector HPLC systems in pharmaceutical analysis KS Lovejoya, DA Ispana, X Yub, P Pinedo-Gonzalezc, M De Praa, C Liuc, D Howerc, D Luc, S Hackbuschd, S Grossea, S Medinga, F Steiner a, A Lambe, J Bardsleye, M…