Improved Reproducibility for Acetaminophen Assay USP Monograph Using MaxPeak™ Premier Columns after Modernization to 2.5 μm Particles

Application Note Modernization of the Acetaminophen USP Monograph Gradient HPLC Method for Impurities using USP <621> Guidelines and MaxPeak™ Premier HPS Technology Kenneth D. Berthelette, Jonathan E. Turner, Thomas H. Walter, Kim Haynes Waters Corporation Abstract USP monographs articulate the…

Application Note Improving USP Monograph Analysis Time Through Scaling by N on an HPLC System Using CORTECS™ Premier Columns Kenneth D. Berthelette, Maureen DeLoffi, Melissa Aiello, Kim Haynes Waters Corporation Abstract The United States Pharmacopeia General Chapter <621> allows certain…

Application Note Improving Analytical Greenness and Analyte Recovery of HPLC Analyses Using 3 mm ID MaxPeak™ Premier Columns Kenneth Berthelette, Christopher Collins, Thomas H Walter Waters Corporation, United States Published on June 15, 2026 Abstract Users of compendial HPLC methods…

Application Note Method Development of Proteolysis Targeting Chimera (PROTAC) Compound ARV-825 Forced Degradation Sample Using the Systematic Screening Protocol Kenneth D. Berthelette, Christopher Collins, Kim Haynes Waters Corporation Abstract Forced degradation studies are one way to determine how a chemical…