Direct and Rapid SEC Analysis of Monoclonal Antibody Titer and Aggregation in Cell- Culture

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

Application Note Automated High-Throughput AnalyticalScale Monoclonal Antibody Purification Using Production-Scale Protein A Affinity Chromatography Resin Stephan M. Koza, Caitlin M. Hanna, Albert H. W. Jiang, Ying Qing Yu Waters Corporation Abstract An automated analytical-scale Protein A affinity based purification of…

Application Note Rapid SEC-UV Analysis of Monoclonal Antibodies Using Ammonium Acetate Mobile Phases Stephan M. Koza, Albert H. W. Jiang, Ying Qing Yu Waters Corporation Abstract A 4 minute high resolution size-exclusion with UV absorbance detection (SEC-UV) method for the…

Application Note An Easy-to-Execute Direct-Connect 2D Protein A–SEC Method for the Analysis of Monoclonal Antibody Titer and Size Variants in Cell Culture Stephan M. Koza, Beatrice Muriithi, Steve Shiner, and Matthew A. Lauber Waters Corporation, United States Published on May…