Rapid Screening of Bispecific Antibodies and Antibody Impurities using In-source Collision Induced Unfolding coupled with IM-MS

Poster Reprint ASMS 2024 Poster number ThP 561 A modified SLIM-IM-QTOF for high resolution collision induced unfolding and native protein analysis Ruwan Kurulugama1, Sarah Stow1, Daniel DeBord2, Greg Kilby2 and Harsha Gunawardena3 1Agilent Technologies, Inc., Santa Clara, CA 2MOBILion Systems,…

Ion Mobility-Mass Spectrometry Reveals the Structures and Stabilities of Biotherapeutic Antibody Aggregates % Daniel D. Vallejo1, Chae K. Jeon1, Kristine F. Parson1, Hayley Herderschee1, Joseph D. Eschweiler2, Ruwan T. Kurulugama3, John C. Fjeldsted3, Dana Filoti2, Brandon T. Ruotolo1 m/z 1Department…

Poster Reprint ASMS 2022 Poster number TP298 Automated sample introduction method for high-throughput intact native protein analysis using collision induced unfolding coupled with drift-tube ion mobility-mass spectrometry Ruwan T. Kurulugama1 and Sheher Banu Mohsin2 1Agilent Technologies, Santa Clara, CA 2Agilent…

Application Note Structural Characterization of Glycated Monoclonal Antibodies Using Collision Induced Unfolding on the SELECT SERIES™ Cyclic™ IMS Mass Spectrometer Kristine Parson, Margo Wilson, Greg Adams, Jason Barker, Dale Cooper-Shepherd FUJIFILM Diosynth Biotechnologies, Waters Corporation Abstract Mass spectrometry-based methods are…