Automated sample introduction method for high-throughput intact native protein analysis using collision induced unfolding coupled with drift-tube ion mobility-mass spectrometry

Poster Reprint ASMS 2024 Poster number ThP 561 A modified SLIM-IM-QTOF for high resolution collision induced unfolding and native protein analysis Ruwan Kurulugama1, Sarah Stow1, Daniel DeBord2, Greg Kilby2 and Harsha Gunawardena3 1Agilent Technologies, Inc., Santa Clara, CA 2MOBILion Systems,…

Poster Reprint ASMS 2023 Poster number ThP 395 Rapid Screening of Bispecific Antibodies and Antibody Impurities using In-source Collision Induced Unfolding coupled with IM-MS Ruwan Kurulugama1, Christian Klein1 ,Harsha Gunawardena2 1Agilent Technologies, Santa Clara, CA 2Janssen Research & Development, Spring…

Add a New Dimension to Your Research Agilent 6560 Ion Mobility LC/Q-TOF Reveal More Details Than Ever Before Does your research involve characterizing small molecules or proteins, increasing metabolite coverage maps, or ensuring food safety? The Agilent 6560 Ion Mobility…

Ion Mobility-Mass Spectrometry Reveals the Structures and Stabilities of Biotherapeutic Antibody Aggregates % Daniel D. Vallejo1, Chae K. Jeon1, Kristine F. Parson1, Hayley Herderschee1, Joseph D. Eschweiler2, Ruwan T. Kurulugama3, John C. Fjeldsted3, Dana Filoti2, Brandon T. Ruotolo1 m/z 1Department…