Targeted Spatial Quantitative Imaging of Metabolites in Paraffin-Embedded Biospecimens

Tracking free-toxin distribution in xenografts after in-vivo ADC dosing by MALDI Imaging MALDI-MRMS imaging of free released toxin in xenografts after ADC in-vivo dosing. Abstract Antibody-drug conjugates (ADC), a fast-growing class of anticancer drugs, typically comprise a cytotoxic payload that…

25 YEARS MALDI High-performance MALDI imaging analysis of on-tissue digested proteins in mammalian FFPE tissues using the Bruker rapifleX MALDI-TOF/TOF In this application note, we describe a workflow for MALDI Mass Spectrometry Imaging (MSI) of proteins from a variety of…

[ TECHNOLOGY BRIEF ] Advantages of Ion Mobility for MALDI Imaging of N-glycans from Tumor Bearing FFPE Tissue in Clinical Research Emmanuelle Claude¹; Peggi M. Angel²; Richard R. Drake.² ¹Waters Corporation, Wilmslow, UK; ²Department of Cell and Molecular Pharmacology and…

MALDI FTMS Imaging Mass Spectrometry of N-glycans as Tissue Biomarkers of Cancer In this application note, we describe preparation and imaging analysis of N-glycans from formalin-fixed paraffin embedded (FFPE) tissues using the solariX MALDI FTMS. N-glycosylation is a common post…