CONFIRM Sequence - A NEW SOFTWARE TOOL FOR SEQUENCE CONFIRMATION AND IMPURITY ANALYSIS OF SYNTHETIC OLIGONUCLEOTIDES Catalin Doneanu1, Mathew Gorton2, Chris Knowles2, Ian Morns3, Chris Preston3, Ian Reah3, Mike Broughton3, Simon Jones3, Jonathan Rewcastle3, Rory Mullins3, Edvinas Karmonas3, Paul Henesey3,…
AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES Catalin Doneanu1, Chris Knowles2, Mathew Gorton3, Joseph Fredette1, Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Newcastle upon Tyne, United Kingdom…
ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIER Catalin Doneanu1, Christopher Knowles2, Jonathan Fox2, Emma Harry2, Ying Qing Yu1, Joseph Fredette1, Ann Grey1 and Weibin Chen1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, UK;…
Application Note CONFIRM Sequence: A waters_connect™ Application for Sequencing of Synthetic Oligonucleotides and Their Impurities Catalin E. Doneanu, Chris Knowles, Matt Gorton, Henry Shion, Joseph Fredette, Ying Qing Yu Waters Corporation Abstract This application note demonstrates an automated, compliance-ready liquid…
