ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIER

CONFIRM Sequence - A NEW SOFTWARE TOOL FOR SEQUENCE CONFIRMATION AND IMPURITY ANALYSIS OF SYNTHETIC OLIGONUCLEOTIDES Catalin Doneanu1, Mathew Gorton2, Chris Knowles2, Ian Morns3, Chris Preston3, Ian Reah3, Mike Broughton3, Simon Jones3, Jonathan Rewcastle3, Rory Mullins3, Edvinas Karmonas3, Paul Henesey3,…

AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Chris Knowles2, Matthew Gorton2, Joe Fredette1 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow, UK RESULTS OVERVIEW…

AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES Catalin Doneanu1, Chris Knowles2, Mathew Gorton3, Joseph Fredette1, Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Newcastle upon Tyne, United Kingdom…

Application Note Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier Catalin E. Doneanu, Chris Knowles, Jonathan Fox, Emma Harry, Ying Qing Yu, Joseph Fredette, Weibin Chen Waters Corporation Abstract This application note demonstrates an automated, compliance-ready LC-MS…