Determination of Oversulfated Chondroitin Sulfate and Dermatan Sulfate in Heparin Sodium Using Anion-Exchange Chromatography with UV Detection

Application Update 178 A Faster Solution with Increased Resolution for Determining Chromatographic Identity and Absence of OSCS in Heparin Sodium INTRODUCTION Heparin is a complex highly sulfated glycosaminoglycan that has been used since the early 20th century as an anticoagulant…

Application Note 233 Determination of Galactosamine Containing Organic Impurities in Heparin by HPAE-PAD Using the CarboPac PA20 Column INTRODUCTION In early 2008, unusual reactions to heparin, including hypotension, swelling of the larynx, and in some cases death, prompted a recall…

Deanna Hurum and Jeffrey Rohrer Thermo Fisher Scientific, Sunnyvale, CA, USA Key Words AminoTrap, Chondroitin Sulfates, Electrochemical Detection , Eluent Generation, RFIC-EG, USP Introduction In early 2008, unusual reactions to heparin, including hypotension, swelling of the larynx, and in some…

Light Scattering for the Masses ® Molecular Weight Determination of Unfractionated Heparin eparin is a polydisperse, heterogeneous polysaccharide derived from animal tissue. Heparin has been used as an anticoagulant for over sixty years and one of the fundamental parameters for…