Comparison of therapeutic antibody originator and biosimilar glycosylation using an integrated glycan labeling solution

[ APPLICATION NOTE ] Increasing Productivity and Confidence for N-linked Glycan Analysis of Biosimilars Using the BioAccord System Ximo Zhang, Corey Reed, Henry Shion, William Alley, Robert Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…

IMPROVING CONFIDENCE AND PRODUCTIVITY FOR N-LINKED GLYCAN ANALYSIS IN BIOTHERAPEUTICS DEVELOPMENT USING AN INTEGRATED UPLC-FLR-HRMS SYSTEM Ximo Zhang; Corey Reed, Henry Shion, Robert Birdsall; Ying Qing Yu Scientific Operations, Waters Corporation, Milford, MA INTRODUCTION RESULTS AND DISCUSSION Due to the…

APPLICATION NOTE 72443 HILIC – an alternative separation technique for glycopeptides Authors Alexander Ley, Martin Samonig, and Mauro De Pra Thermo Fisher Scientific, Germering, Germany Goal Demonstrate the suitability of the Thermo Scientific™ Vanquish™ Flex UHPLC system and Thermo Scientific™…

Waters Application Notes Glycans There are a variety of complementary techniques practiced to get the complete story about a glycoprotein. Each technique varies in complexity and provides a different layer of information. Method complexity This application notebook highlights a body…