Titration Karl Fischer
IndustriesManufacturerMetrohm
Importance of the topic
The integration of dosing, stirring and control into a compact titration unit addresses growing demands in analytical laboratories for space-saving, efficient and highly reliable routine analysis. Modern quality control, research and industrial environments benefit from systems that ensure data security, regulatory compliance and seamless network integration without dependence on a PC.
Objectives and overview
This application note presents the Metrohm Ti-Touch family of compact titrators (models 916 Ti-Touch, 915 KF Ti-Touch and 917 Coulometer) alongside the 810 Sample Processor. It aims to demonstrate how these instruments streamline potentiometric, volumetric and coulometric titrations, enhance automation, and support data management under FDA-compliant conditions.
Methodology and instrumentation
The Ti-Touch series integrates intelligent dosing elements (Dosino/Dosimat), built-in stirrers (rod or magnetic), exchangeable electrodes (“iTrodes”) and programmable polarizers. Key interfaces include USB, Ethernet and Metrohm Serial Bus (MSB) ports for peripherals such as sample changers, printers, barcode readers and LIMS connectivity. The 916 Ti-Touch supports dynamic (DET), monotonic (MET) and endpoint-based titrations (SET), as well as pH/enzymatic (STAT) and manual (MAT) modes. The 915 KF Ti-Touch performs volumetric Karl Fischer titrations, while the 917 Coulometer handles coulometric KF and bromine index determinations. The 810 Sample Processor automates dosing and titration of up to 24 samples with precision membrane pumping and optional external pumps for waste handling.
Main results and discussion
These compact systems deliver:
- High throughput through automation and plug-and-play component recognition.
- Safe, contact-free reagent replacement via patented Dosino technology.
- Robust data handling: on-device PDF report generation, USB and network storage, LIMS integration and audit trail for full traceability.
- Regulatory compliance: FDA 21 CFR Part 11 support, user management and electronic signatures.
Integration with tiBase software further enables centralized data archiving, re-processing of results, and customizable reporting formats.
Benefits and practical applications
The Ti-Touch platforms are ideally suited for quality assurance and quality control in pharmaceutical, food, chemical and petrochemical laboratories. Their minimized footprint and network capabilities make them attractive for facilities seeking paperless workflows, secure data archives and rapid method switching via personalized touchscreen favorites. The 810 Sample Processor extension ensures reproducible unattended analyses, reducing operator exposure to reagents and improving laboratory safety.
Future trends and potential applications
Further development may include enhanced real-time data analytics, cloud-based instrument monitoring and AI-driven method optimization. Expansion of modular accessories and integration with automated sample preparation systems will continue to elevate throughput and reproducibility. Adoption of IoT standards could facilitate predictive maintenance and remote calibration services.
Conclusion
The Metrohm Ti-Touch series, complemented by the 810 Sample Processor, represents a modern solution for routine titrimetric analysis. By consolidating dosing, stirring, measurement and data management into compact, FDA-compliant instruments, laboratories achieve greater efficiency, data integrity and operational flexibility without reliance on a dedicated PC.
Reference
Metrohm application note on Ti-Touch titrators and accessories (product documentation).
Content was automatically generated from an orignal PDF document using AI and may contain inaccuracies.